Multi-region ICD-10 codes

Staphylococcal pyogenic arthritis affecting multiple joints simultaneously, not limited to a single anatomical site.

M00.19 identifies pneumococcal pyogenic arthritis involving multiple joints simultaneously, caused by Streptococcus pneumoniae infection, where no single dominant joint site can be specified.

Streptococcal joint infection involving multiple joints simultaneously, caused by streptococcal species other than group A (Streptococcus pyogenes) and group B (Streptococcus agalactiae), where no single joint site predominates.

Bacterial infection involving multiple joints simultaneously, caused by a pathogen other than staphylococcal, pneumococcal, streptococcal, or gonococcal organisms — classified under the pyogenic arthritis category.

M01.X9 identifies direct microbial invasion of multiple joints as a manifestation of an underlying infectious or parasitic disease that is coded and classified elsewhere in ICD-10-CM.

Joint disease affecting multiple anatomical sites as a direct consequence of intestinal bypass surgery, classified under postinfective and reactive arthropathies.

Reactive joint inflammation affecting multiple anatomical sites, occurring as a sequela of dysenteric gastrointestinal infection — classified under postinfective and reactive arthropathies.

M02.29 identifies postimmunization arthropathy affecting multiple joint sites simultaneously — a reactive joint condition that develops following vaccination rather than from direct pathogen invasion of the joint.

Reiter's disease (reactive arthritis) affecting multiple joint sites simultaneously, coded when two or more anatomically distinct joints are involved and no single-site code captures the full clinical picture.

M02.89 identifies reactive arthropathy affecting multiple joint sites simultaneously, triggered by an infection elsewhere in the body rather than direct joint invasion by a pathogen.

Felty's syndrome coded at the unspecified-site level — rheumatoid arthritis with positive rheumatoid factor, splenomegaly, and granulocytopenia/neutropenia, where the affected joint site is not documented.

Felty's syndrome affecting multiple joint sites simultaneously — the triad of seropositive rheumatoid arthritis, splenomegaly, and granulocytopenia documented across more than one anatomical region.

Rheumatoid lung disease occurring concurrently with seropositive rheumatoid arthritis affecting multiple joint sites simultaneously, captured under a single billable code when bilateral or polyarticular involvement is present alongside pulmonary manifestation.

Rheumatoid vasculitis with seropositive rheumatoid arthritis affecting multiple joint sites simultaneously, representing a severe systemic complication where vascular inflammation is present alongside polyarticular disease.

Seropositive rheumatoid arthritis affecting the heart (carditis, endocarditis, myocarditis, or pericarditis) in a patient whose joint disease involves multiple anatomical sites simultaneously.

Rheumatoid myopathy occurring as an extraarticular manifestation of seropositive rheumatoid arthritis, documented at multiple joint sites simultaneously.

Rheumatoid polyneuropathy with seropositive (rheumatoid factor–positive) rheumatoid arthritis affecting multiple joint sites simultaneously.

Seropositive rheumatoid arthritis affecting multiple joint sites simultaneously, with documented involvement of one or more organs or body systems beyond the joints themselves.

Seropositive rheumatoid arthritis affecting multiple joints simultaneously, confirmed by positive rheumatoid factor, with no documented involvement of organs or organ systems beyond the musculoskeletal system.

Seropositive rheumatoid arthritis that does not fit the more specifically defined M05 subcategories, with the affected anatomical site undocumented or unspecified in the clinical record.

Rheumatoid arthritis confirmed by positive rheumatoid factor (RF) seropositivity, classified under the 'other' subcategory of M05.8, affecting multiple joint sites simultaneously rather than a single anatomic location.

Seronegative rheumatoid arthritis affecting three or more distinct joint regions simultaneously, with negative rheumatoid factor lab results documented in the medical record.

Rheumatoid bursitis affecting two or more anatomically distinct joint sites simultaneously, classified under other rheumatoid arthritis (M06) when bursal inflammation is the primary manifestation across multiple regions.

Rheumatoid nodule, multiple sites — subcutaneous or deep-tissue nodules associated with rheumatoid arthritis occurring at more than one anatomical location simultaneously.

M06.89 captures other specified rheumatoid arthritis affecting multiple joint sites simultaneously, used when the RA subtype does not carry a positive rheumatoid factor and the polyarticular presentation spans joints that cannot be collapsed into a single anatomic site code.

Inflammatory joint disease linked to an underlying gastrointestinal condition — such as Crohn's disease or ulcerative colitis — where the specific joint site has not been documented or identified.

Enteropathic arthropathy affecting multiple joint sites simultaneously, coded when inflammatory bowel disease (Crohn's disease or ulcerative colitis) drives joint involvement across more than one anatomical region.

Juvenile rheumatoid arthritis (with or without rheumatoid factor) in a patient under 16, where the subtype and affected joint site are both undocumented or indeterminate at the time of coding.

Unspecified juvenile rheumatoid arthritis affecting multiple joint sites simultaneously, where the specific subtype cannot be determined from available documentation.

Systemic-onset juvenile rheumatoid arthritis (Still's disease in children) involving multiple joint sites simultaneously, requiring both systemic features and multi-site joint documentation to support the code.

Other juvenile arthritis affecting multiple joint sites simultaneously, used when the specific JA subtype does not fit a more defined M08 category and involvement spans more than one discrete anatomical region.

M08.99 identifies juvenile arthritis of unspecified type involving multiple joint sites simultaneously in a patient under 16 years of age at onset, where the specific subtype of juvenile arthritis has not been documented.

Idiopathic gout affecting multiple joints simultaneously, where no identifiable secondary cause (such as medication, renal disease, or lead exposure) underlies the hyperuricemia and crystal deposition.

Lead-induced gout affecting multiple joint sites simultaneously, classified under secondary gout caused by toxic lead exposure.

Drug-induced gout affecting multiple joint sites simultaneously, where a causative medication is responsible for triggering urate crystal deposition and inflammatory arthritis across more than one anatomical location.

Gout caused by renal impairment affecting multiple joint sites simultaneously — classified under secondary gout with a mandatory 'code first' instruction for the underlying renal disease.

Secondary gout involving multiple joint sites simultaneously, where the hyperuricemia and resulting gouty arthritis stem from an identifiable underlying condition other than lead exposure, renal impairment, or drug use.

Hydroxyapatite deposition disease (HADD) involving two or more anatomically distinct joint sites simultaneously, classified under the crystal arthropathy family of diagnoses.

Familial chondrocalcinosis with no specific joint site documented — a hereditary crystal arthropathy characterized by calcium pyrophosphate dihydrate (CPPD) deposits in cartilage, assigned when the affected joint is not identified in the record.

Familial chondrocalcinosis affecting multiple joint sites simultaneously, caused by an inherited predisposition to calcium pyrophosphate dihydrate (CPPD) crystal deposition in articular cartilage.

Calcium pyrophosphate dihydrate (CPPD) crystal deposition affecting cartilaginous structures across two or more distinct joint sites, classified under other chondrocalcinosis when not attributable to a single anatomic location.

Crystal-induced inflammatory arthritis affecting multiple joint sites simultaneously, where the specific crystal type is identified but does not fall under gout or calcium pyrophosphate deposition (CPPD) disease categories.

Jaccoud arthropathy affecting multiple joint sites simultaneously — a chronic, deforming arthropathy that develops as a sequela of repeated rheumatic inflammation, characterized by reducible joint deformities without significant cartilage destruction.

Kaschin-Beck disease affecting multiple joint sites simultaneously — a chronic, disabling osteochondrodysplasia characterized by osteosclerosis, cone-shaped metaphyses, and diaphyseal shortening involving more than one anatomical region.

Pigmented villonodular synovitis (PVNS) confirmed at two or more distinct joint sites simultaneously, classified under other and unspecified arthropathy in Chapter 13.

Palindromic rheumatism affecting multiple joint sites simultaneously, coded when the clinician documents episodic, self-resolving arthritis flares involving more than one anatomical region without a single dominant site.

Recurrent, self-resolving fluid accumulation affecting multiple joints simultaneously, classified under other and unspecified arthropathy in the musculoskeletal chapter.

Traumatic arthropathy affecting two or more joint sites simultaneously, where joint damage results from prior trauma rather than a systemic or degenerative process.

M12.89 classifies a specific arthropathy that does not fit any more precisely defined joint disease category and affects two or more distinct anatomical sites simultaneously.

Arthritis affecting multiple anatomical sites that falls under a specified type but does not fit any more precisely defined ICD-10-CM category — used when the arthritis type is documented but no single-site or disease-specific code applies.

Neuropathic arthropathy (Charcot's joint) affecting two or more anatomically distinct joint sites simultaneously, where the underlying neurological disease has caused progressive joint destruction across multiple regions of the body.

Arthropathy affecting multiple joint sites as a direct manifestation of another specified underlying disease coded elsewhere in ICD-10-CM — not a standalone primary diagnosis.

Acquired discrepancy in length between paired limbs (upper or lower) when the specific anatomical site cannot be or has not been documented.

M21.80 captures acquired deformities of a limb that are neither congenital nor classifiable to a more specific M21 subcategory, where the affected limb is not documented.

An acquired (non-congenital) deformity affecting a limb where neither the specific limb nor the type of deformity is documented or identifiable from the clinical record.

M35.81 classifies multisystem inflammatory syndrome (MIS) — a serious, hyperinflammatory condition affecting multiple organ systems, seen in both children (MIS-C) and adults (MIS-A), and strongly associated with prior SARS-CoV-2 infection.

Infective myositis affecting skeletal muscle at multiple anatomic sites simultaneously, caused by a bacterial, viral, fungal, or parasitic organism.

Interstitial myositis involving two or more anatomical muscle sites, classified under non-infective inflammatory muscle disorders in Chapter 13.

Inflammatory muscle disease affecting two or more anatomically distinct sites, classified as 'other' myositis when it does not fall under infective, foreign body, or calcifying subtypes.

Traumatic myositis ossificans affecting two or more distinct muscle sites simultaneously, classified under calcification and ossification of muscle disorders.