ICD-10-CM · Multi-region

M10.49

Secondary gout involving multiple joint sites simultaneously, where the hyperuricemia and resulting gouty arthritis stem from an identifiable underlying condition other than lead exposure, renal impairment, or drug use.

Verified May 8, 2026 · 6 sources ↓

Status
Billable
Chapter
13
Related CPT
10
Region
Multi-region
Drawn from CDCICD10DataAAPCPrecisionhubCMS

Documentation tips

What should appear in the chart to support M10.49.

Source · Editorial brief grounded in 6 cited references ↓

  • Name each affected joint explicitly (e.g., right first MTP and left wrist) — 'multiple joints' without specificity is insufficient to justify this code over a single-site code.
  • Document the underlying cause of secondary gout by diagnosis, not just the lab finding; a serum urate level alone does not establish secondary etiology.
  • Record whether this is an acute flare or chronic/tophaceous presentation — chronic gout maps to M1A.49, not M10.49.
  • Sequence the causative condition first per the M10.4 'Code First associated condition' instruction and note that linkage explicitly in the encounter documentation.
  • Capture any associated organ manifestations (renal calculi, cardiomyopathy, glomerulonephritis) so coders can append the required additional codes at the M10 category level.
  • Distinguish 'other secondary gout' from drug-induced (M10.1x), lead-induced (M10.2x), and renal-impairment gout (M10.3x) — document that none of these specific etiologies apply if coding M10.49.

Related CPT procedures

Procedure codes commonly billed with M10.49. Linking the right diagnosis to the right procedure is what establishes medical necessity.

Source · CMS LCDs · AAOS specialty guidance · claims-pattern analysis

Common coding pitfalls

The recurring mistakes coders make with M10.49 and adjacent codes.

Source · Editorial brief grounded in CDC ICD-10-CM tabular guidance, AAOS coding references, and cited references ↓

  • Sequencing M10.49 first when a 'Code First' underlying condition is present — the causative systemic disease belongs in the primary position.
  • Using M10.49 for chronic tophaceous gout at multiple sites — that presentation requires M1A.49, since M10 is limited to acute gout/gout flares and chronic gout is Excludes2.
  • Defaulting to M10.9 (unspecified gout) when the record documents both a secondary etiology and polyarticular involvement — M10.49 is the correct billable code in that scenario.
  • Conflating renal-impairment secondary gout (M10.39) with 'other' secondary gout (M10.49) — if chronic kidney disease or renal dysfunction is the documented cause, use M10.3x, not M10.4x.
  • Assigning M10.49 when only one joint is affected — use the appropriate single-site M10.4x code (M10.40–M10.47) when laterality and site are documented.

Clinical context

Source · Editorial summary grounded in 6 cited references ↓

M10.49 applies when a patient presents with acute gouty arthritis affecting more than one joint region and the gout is attributable to a secondary cause — such as a hematologic disorder, enzyme deficiency, or another systemic disease — that does not fall under the drug-induced (M10.1x), lead-induced (M10.2x), or renal-impairment-related (M10.3x) subcategories. The 'multiple sites' qualifier requires documentation of polyarticular involvement; if the flare is confined to a single joint region, select the site-specific M10.4x code instead.

Critical sequencing rule: M10.4x carries a 'Code First' instruction for the associated underlying condition. The causative disorder (e.g., a hematologic malignancy, glucose-6-phosphatase deficiency, or other metabolic disease) must be sequenced before M10.49 unless the reason for the encounter is the gout itself — follow standard ICD-10-CM sequencing guidelines for that determination. Chronic gout is explicitly excluded from this category (Excludes2: M1A.-).

Because M10.49 covers acute flares, verify the encounter is not for chronic tophaceous gout, which belongs under M1A.49. Use additional codes as instructed at the M10 category level to capture any associated manifestations: autonomic neuropathy (G99.0), uric acid urolithiasis (N22), cardiomyopathy (I43), or glomerular disease (N08).

Sibling codes

Other billable codes under M10.4 (laterality / anatomic variants).

Frequently asked questions

Source · Generated from the editorial pipeline, verified against 6 cited references ↓

01What qualifies as 'multiple sites' for M10.49?
Documentation must identify gouty arthritis in more than one distinct anatomic joint region during the same encounter. 'Bilateral MTP joints' may qualify; a single joint with referred pain does not.
02Which secondary causes of gout belong under M10.49 versus M10.3x?
M10.3x (gout due to renal impairment) is reserved when chronic kidney disease or another renal disorder is the documented driver. M10.49 covers all other secondary etiologies — hematologic disease, enzyme defects, and similar systemic conditions not classified as drug-, lead-, or renal-related.
03Does M10.49 require a 'Code First' companion code?
Yes. The M10.4 parent carries a 'Code First associated condition' instruction. The underlying systemic cause must be coded and, in most encounters, sequenced before M10.49.
04How do I distinguish M10.49 from M1A.49?
M10.49 is for acute gout flares and attacks at multiple sites. M1A.49 (other secondary chronic gout, multiple sites) applies when the provider documents chronic or tophaceous gout. If the note describes an acute attack or flare, use M10.49.
05Can M10.49 be used for drug-induced polyarticular gout?
No. Drug-induced gout maps to M10.1x regardless of site count. Reserve M10.49 for secondary gout whose etiology is neither drug-induced, lead-induced, nor renal-impairment-related.
06Should I add additional codes for organ manifestations when reporting M10.49?
Yes. The M10 category instructs coders to use additional codes for associated manifestations including autonomic neuropathy (G99.0), uric acid urolithiasis (N22), cardiomyopathy (I43), and glomerular disease (N08) when documented.
07What CPT procedures are commonly billed with M10.49?
Joint aspiration or injection of a major joint (20610) or intermediate joint (20605) for diagnostic or therapeutic purposes during an acute flare are the most common procedural companions, along with office E&M codes when the encounter is primarily management-focused.

Mira AI Scribe

The Mira AI Scribe captures polyarticular joint involvement by name, the documented underlying systemic condition driving uric acid overproduction or underexcretion, acute flare status versus chronic tophaceous presentation, and any associated organ findings (renal stones, nephropathy). This prevents defaulting to unspecified M10.9, missing the mandatory 'Code First' sequencing instruction, and incorrect migration to M1A.49 for what is actually an acute flare.

See how Mira captures M10.49 documentation

Related ICD-10 codes

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