Ankylosing spondylitis localized to the lumbosacral region of the spine, capturing inflammatory involvement at the junction of the lumbar vertebrae and sacrum.
Verified May 8, 2026 · 5 sources ↓
- Status
- Billable
- Chapter
- 13
- Related CPT
- 12
- Region
- Spine
Documentation tips
What should appear in the chart to support M45.7.
Source · Editorial brief grounded in 5 cited references ↓
- Explicitly name the lumbosacral region in the clinical note — 'lumbar' or 'sacral' alone maps to a different M45 subcategory.
- Document HLA-B27 test result and date, as this supports inflammatory versus degenerative diagnosis distinction.
- Record radiographic or MRI findings: sacroiliitis grade, syndesmophytes, or erosions at the lumbosacral junction.
- Note the duration and pattern of back pain (morning stiffness, nocturnal pain, improvement with activity) to establish inflammatory back pain criteria.
- If multiple spinal regions are involved, document each region explicitly so the coder can determine whether M45.0 or M45.7 applies.
- Record elevated inflammatory markers (CRP, ESR) in the same encounter note to support active inflammatory disease coding.
Related CPT procedures
Procedure codes commonly billed with M45.7. Linking the right diagnosis to the right procedure is what establishes medical necessity.
Source · CMS LCDs · AAOS specialty guidance · claims-pattern analysis
Common coding pitfalls
The recurring mistakes coders make with M45.7 and adjacent codes.
Source · Editorial brief grounded in CDC ICD-10-CM tabular guidance, AAOS coding references, and cited references ↓
- Reporting M45 (non-billable parent) instead of M45.7 — the parent code will be rejected; always code to the 4th-character level.
- Confusing M45.6 (lumbar region) with M45.7 (lumbosacral region) — the lumbosacral code applies only when the provider documents involvement at the L5-sacrum junction, not the lumbar spine broadly.
- Using M45.7 when the diagnosis is juvenile ankylosing spondylitis — that maps to M08.1, which is an Excludes1 exclusion at the M45 category level.
- Applying M45.7 when Reiter's disease (reactive arthritis) is the underlying cause of spinal arthropathy — use M02.3- instead.
- Defaulting to M45.9 (unspecified site) when the note documents lumbosacral involvement — M45.9 is a valid code but signals incomplete documentation and may not satisfy LCD specificity requirements.
Clinical context
Source · Editorial summary grounded in 5 cited references ↓
M45.7 is the correct billable code when the provider documents ankylosing spondylitis (AS) with involvement specifically at the lumbosacral region — the transitional zone between L5 and the sacrum. This is distinct from M45.6 (lumbar region only) and M45.8 (sacral and sacrococcygeal region). If the documented involvement spans multiple spinal regions, use M45.0 instead. Never report the parent code M45 alone — it is non-billable and will trigger a claim rejection.
The lumbosacral region is a common site of early AS involvement given its proximity to the sacroiliac joints. Supporting documentation typically includes radiographic sacroiliitis, HLA-B27 status, inflammatory back pain history (onset before age 45, worse with rest, improved with movement), and elevated CRP or ESR. These findings anchor the diagnosis and satisfy LCD/NCD criteria when applicable.
For AS, the Excludes1 notes at the M45 category level are critical: do not use M45.7 when the underlying condition is arthropathy in Reiter's disease (M02.3-) or juvenile ankylosing spondylitis (M08.1). Behçet's disease (M35.2) is listed as Excludes2, meaning it can be coded separately if both conditions are independently documented.
Sibling codes
Other billable codes under M45 (laterality / anatomic variants).
Frequently asked questions
Source · Generated from the editorial pipeline, verified against 5 cited references ↓
01What is the difference between M45.6 and M45.7?
02Can I use M45.7 if the note says ankylosing spondylitis without specifying the region?
03Is M45.7 appropriate for juvenile ankylosing spondylitis in the lumbosacral region?
04Does M45.7 require a 7th-character extension?
05What if the patient has AS affecting both the lumbosacral region and the thoracic spine?
06Can M45.7 be coded alongside a sacroiliac joint injection CPT code?
07Does Behçet's disease exclude the use of M45.7?
Sources & references
Editorial content was developed using the following public sources. Last verified May 8, 2026.
- 01CDC ICD-10-CM Tabular List 2026 (effective Oct 1, 2025)
- 02icd10data.comhttps://www.icd10data.com/ICD10CM/Codes/M00-M99/M45-M49/M45-/M45.7
- 03aapc.comhttps://www.aapc.com/codes/icd-10-codes/M45.7
- 04asahq.orghttps://www.asahq.org/~/media/sites/asahq/files/public/resources/practice%20management/ttppm/2015-08-28-cms-ama-guidance-on-the-icd-10-transition-what-does-it-really-mean.pdf
- 05cdek.pharmacy.purdue.eduhttps://cdek.pharmacy.purdue.edu/icd10/M45/
Mira AI Scribe
Mira's AI scribe captures the provider's documented spinal region (lumbosacral), inflammatory back pain characteristics, HLA-B27 result, and imaging findings (sacroiliitis grade, syndesmophytes) at the point of encounter. This prevents downcoding to the unspecified M45.9, blocks rejection from the non-billable M45 parent, and ensures the record supports LCD/NCD criteria for biologic therapy authorizations tied to confirmed AS diagnosis.
See how Mira captures M45.7 documentation