ICD-10-CM · General

M85.40

M85.40 identifies a solitary bone cyst at an unspecified skeletal site — a benign, fluid-filled unilocular lytic lesion with well-defined endosteal margins, reported when the operative or imaging report does not specify which bone is affected.

Verified May 8, 2026 · 5 sources ↓

Status
Billable
Chapter
13
Related CPT
8
Region
General
Drawn from CDCICD10DataAAPC

Documentation tips

What should appear in the chart to support M85.40.

Source · Editorial brief grounded in 5 cited references ↓

  • Name the specific bone affected — proximal humerus, proximal femur, tibia, etc. — so coders can assign a site-specific M85.4x code instead of the unspecified fallback M85.40.
  • Record laterality explicitly (right or left) in every encounter note and operative report; M85.4x codes offer right/left options at the 6th character.
  • Document imaging modality and findings: confirm unilocular appearance, fluid content, and narrow endosteal margins on X-ray or MRI to support the solitary bone cyst diagnosis over other lytic lesions.
  • If aspiration or steroid injection (CPT 20615) was performed, link the procedure note to the diagnosis note so the cyst site is consistently documented across both.
  • Distinguish from jaw cysts in the record; a solitary cyst of the jaw requires M27.4, not M85.40, and mixing the two will trigger an Excludes2 conflict.

Related CPT procedures

Procedure codes commonly billed with M85.40. Linking the right diagnosis to the right procedure is what establishes medical necessity.

Source · CMS LCDs · AAOS specialty guidance · claims-pattern analysis

Common coding pitfalls

The recurring mistakes coders make with M85.40 and adjacent codes.

Source · Editorial brief grounded in CDC ICD-10-CM tabular guidance, AAOS coding references, and cited references ↓

  • Defaulting to M85.40 when the operative or radiology report clearly names the bone — always check for a site-specific M85.4x child code before using the unspecified fallback.
  • Coding a jaw cyst to M85.40 instead of M27.4; the Excludes2 note at M85.4 explicitly carves out solitary cyst of jaw.
  • Confusing solitary bone cyst with fibrous dysplasia (M85.0x) or aneurysmal bone cyst — these are distinct pathologies with distinct codes; rely on pathology or imaging confirmation before assigning.
  • Applying M85.40 to conditions in the M85 Excludes1 list (osteogenesis imperfecta, osteopetrosis, osteopoikilosis, polyostotic fibrous dysplasia) — those are genetic/systemic conditions coded to the Q78 range and cannot be reported alongside M85.40.
  • Omitting laterality when a site-specific code is available; M85.40 does not carry laterality granularity, so using it when the bone is documented sacrifices specificity that payers and auditors expect.

Clinical context

Source · Editorial summary grounded in 5 cited references ↓

Use M85.40 only when documentation genuinely fails to identify the affected bone or skeletal region. Solitary bone cysts (also called unicameral bone cysts) are benign lesions most commonly found in the proximal humerus or proximal femur, typically in male patients between ages 3 and 15. The cyst cavity contains fluid and may have walls with scattered giant cells. Imaging characteristically shows a unilocular lytic area with narrow, well-defined endosteal margins.

The M85.4 subcategory contains site-specific codes extending through shoulder (M85.41x), humerus (M85.42x), ulna and radius (M85.43x), and additional long bone locations — all with right/left laterality options. M85.40 should be a last resort, not a default. If the physician's note, operative report, or imaging study names the bone, assign the site-specific code instead.

Note the Excludes2 instruction at M85.4: solitary cyst of jaw is coded separately to M27.4 and must not be reported with M85.40. Additionally, M85 carries Excludes1 restrictions against coding conditions such as osteogenesis imperfecta (Q78.0), osteopetrosis (Q78.2), osteopoikilosis (Q78.8), and polyostotic fibrous dysplasia (Q78.1) — none of which are interchangeable with a solitary bone cyst.

Sibling codes

Other billable codes under M85.4 (laterality / anatomic variants).

Frequently asked questions

Source · Generated from the editorial pipeline, verified against 5 cited references ↓

01When is M85.40 appropriate versus a site-specific M85.4x code?
Use M85.40 only when the clinical documentation — including imaging reports and operative notes — does not identify which bone contains the cyst. If any source in the record names the bone, assign the matching site-specific code (e.g., M85.421 for right humerus).
02Does M85.40 require a 7th character?
No. M85.40 is an M-code (musculoskeletal chapter) and does not use 7th-character encounter extensions. Those extensions (A/D/S) apply to injury S-codes, not to chronic bone condition codes in Chapter 13.
03Can M85.40 be used for a jaw cyst?
No. The Excludes2 note at M85.4 explicitly directs solitary cyst of jaw to M27.4. Assign M27.4 for jaw cysts; M85.40 is reserved for skeletal sites outside the jaw.
04What CPT codes are commonly paired with M85.40 in orthopedic practice?
Aspiration and injection of bone cyst (20615) is the most common procedural pairing. Open excision of bone cyst codes such as 23140 (shoulder/clavicle), 24120 (humerus), 27065–27070 (pelvis/femur), and imaging codes 73221 or 73721 (MRI upper or lower extremity) are also frequently linked, depending on the treatment and diagnostic workup.
05What MS-DRG does M85.40 group into?
M85.40 groups to MS-DRG 553 (Bone diseases and arthropathies with MCC) or MS-DRG 554 (Bone diseases and arthropathies without MCC), per MS-DRG v43.0.
06Is M85.40 a new code for FY2026?
No. M85.40 has been active and unchanged since the initial ICD-10-CM implementation effective October 1, 2015, and carries no revisions through the FY2026 code set.
07How do solitary bone cysts differ clinically from aneurysmal bone cysts, and does that affect coding?
Solitary (unicameral) bone cysts are unilocular, fluid-filled, and typically metaphyseal in long bones. Aneurysmal bone cysts are multilocular, blood-filled, and coded separately (M85.5x). Pathology or MRI findings drive the distinction — assign M85.40 only when the diagnosis is confirmed as a solitary cyst, not an aneurysmal variant.

Mira AI Scribe

Mira AI Scribe captures the bone name, laterality, lesion characteristics (unilocular vs. multilocular, fluid vs. solid), and imaging modality from the encounter to support a site-specific M85.4x code. Without that detail, the claim lands on M85.40 — unspecified site — which can trigger medical necessity scrutiny and leaves clinical specificity on the table.

See how Mira captures M85.40 documentation

Related ICD-10 codes

Ready?

Ready to transform your orthopedic practice?

See how orthopedic practices are running documentation, billing, and operations on a single voice-first platform.

Get started for free