ICD-10-CM · Other

M27.2

M27.2 classifies bone and periosteal inflammatory conditions of the jaw, including osteitis, osteomyelitis, osteoradionecrosis, periostitis, and sequestrum of jaw bone.

Verified May 8, 2026 · 5 sources ↓

Status
Billable
Chapter
13
Related CPT
10
Region
Other
Drawn from CDCICD10DataAAPCUnboundmedicineCMS

Documentation tips

What should appear in the chart to support M27.2.

Source · Editorial brief grounded in 5 cited references ↓

  • Specify the jaw affected (mandible vs. maxilla) and whether the process is unilateral or bilateral — M27.2 has no laterality subcode, but surgical records and imaging reports should reflect this for medical necessity.
  • If radiation is the documented cause, the provider note must explicitly link the jaw condition to radiation history; this supports appending W88–W90 or X39.0 as a secondary code.
  • Document the specific inflammatory diagnosis by name (e.g., 'osteomyelitis of mandible,' 'osteoradionecrosis of jaw,' 'periostitis') rather than generic 'jaw infection' — the Applicable To list terms map directly to M27.2 and support code assignment.
  • When bisphosphonate or antiresorptive drug therapy is the documented precipitating factor, the provider must state this clearly so the coder can route to M87.180 instead of M27.2.
  • Include staging or severity information (e.g., AAOMS staging for BRONJ/MRONJ, extent of bone exposure, presence of sequestrum) to support medical necessity for surgical intervention.

Related CPT procedures

Procedure codes commonly billed with M27.2. Linking the right diagnosis to the right procedure is what establishes medical necessity.

Source · CMS LCDs · AAOS specialty guidance · claims-pattern analysis

Common coding pitfalls

The recurring mistakes coders make with M27.2 and adjacent codes.

Source · Editorial brief grounded in CDC ICD-10-CM tabular guidance, AAOS coding references, and cited references ↓

  • Coding M27.2 for medication-related osteonecrosis of the jaw (MRONJ): the Excludes2 note directs that condition to M87.180; using M27.2 alone misclassifies the etiology and may trigger a payer query.
  • Omitting the secondary radiation cause code (W88–W90 or X39.0) when osteoradionecrosis is documented — the 'Use Additional Code' instruction is mandatory when radiation etiology is established, not discretionary.
  • Confusing M27.2 with M27.3 (alveolitis of jaws, i.e., dry socket): alveolitis is a separate code for post-extraction alveolar inflammation and should not be coded to M27.2.
  • Using M27.2 for temporomandibular joint (TMJ) inflammatory conditions: TMJ arthritis and synovitis map to M26.6x codes, not M27.2, which is limited to bone and periosteal pathology of the jaw.

Clinical context

Source · Editorial summary grounded in 5 cited references ↓

M27.2 covers a spectrum of inflammatory bone pathology affecting the mandible or maxilla. The 'Applicable To' list includes osteitis of the jaw(s), neonatal osteomyelitis of the jaw(s), osteoradionecrosis of the jaw(s), periostitis of the jaw(s), and sequestrum of jaw bone. These conditions share a common feature: infectious, ischemic, or radiation-driven breakdown of jaw bone or periosteum rather than a developmental or neoplastic process.

When the inflammatory condition is radiation-induced — most commonly osteoradionecrosis following head and neck radiation therapy — add a secondary code from W88–W90 or X39.0 to identify the radiation source. This is a 'Use Additional Code' instruction, not optional. Failure to append the radiation cause code when the record documents radiation history is an incomplete claim.

M27.2 carries an Excludes2 note for osteonecrosis of jaw due to drug (M87.180). If the provider documents medication-related osteonecrosis of the jaw (MRONJ) — typically from bisphosphonates or denosumab — do not use M27.2; code M87.180 instead. The Excludes2 designation means both codes could theoretically coexist when distinct processes are present, but MRONJ should be classified to M87.180 as the primary pathology.

Inclusion & exclusion notes

Per the official ICD-10-CM Tabular List.

Source · CDC ICD-10-CM Official Tabular List · 2026

Includes

  • Osteitis of jaw(s)
  • Osteomyelitis (neonatal) jaw(s)
  • Osteoradionecrosis jaw(s)
  • Periostitis jaw(s)
  • Sequestrum of jaw bone

Excludes 2 — may coexist if both documented

  • osteonecrosis of jaw due to drug (M87.180)

Sibling codes

Other billable codes under M27 (laterality / anatomic variants).

Frequently asked questions

Source · Generated from the editorial pipeline, verified against 5 cited references ↓

01Does M27.2 require a secondary code when the jaw condition is radiation-induced?
Yes. The tabular instruction says 'Use additional code (W88–W90, X39.0) to identify radiation, if radiation-induced.' This is mandatory when the record documents radiation as the cause — it is not optional.
02Should M27.2 be used for medication-related osteonecrosis of the jaw (MRONJ)?
No. The Excludes2 note directs osteonecrosis of jaw due to drug to M87.180. If the provider documents that bisphosphonates, denosumab, or another antiresorptive/antiangiogenic drug caused the jaw osteonecrosis, code M87.180, not M27.2.
03Is M27.2 laterality-specific?
No. M27.2 has no 6th-character laterality subdivision. Laterality (mandible vs. maxilla, left vs. right) should be documented in the clinical record and operative note for surgical planning and medical necessity, but the ICD-10-CM code itself does not distinguish sides.
04What is the difference between M27.2 and M27.3?
M27.3 is alveolitis of jaws (dry socket), a post-extraction inflammatory condition of the alveolar socket. M27.2 covers deeper bone pathology — osteomyelitis, osteoradionecrosis, periostitis, and sequestrum. They are sibling codes under M27 and are not interchangeable.
05Can M27.2 be used for TMJ arthritis or synovitis?
No. Temporomandibular joint inflammatory conditions map to the M26.6x code range. M27.2 applies to inflammatory bone and periosteal conditions of the jaw structure itself, not the TMJ.
06What CPT procedures are commonly linked to M27.2?
Surgical sequestrectomy or debridement of infected jaw bone (e.g., 21025, 21026), excision of benign lesion or cyst (21040), partial mandibulectomy (21044, 21045), and jaw imaging such as CT of the maxillofacial area (70486) are common procedural companions when M27.2 is the primary diagnosis.
07Is neonatal osteomyelitis of the jaw coded to M27.2?
Yes. 'Osteomyelitis (neonatal) jaw(s)' appears explicitly in the Applicable To list under M27.2, making it the correct code regardless of patient age at onset when the jaw is the affected site.

Mira AI Scribe

Mira's AI scribe captures the specific inflammatory diagnosis (osteomyelitis, osteoradionecrosis, periostitis, sequestrum), the jaw location (mandible or maxilla), any documented radiation or drug history, and imaging findings such as cortical destruction or sequestrum on CT/panoramic X-ray. Precise capture of radiation cause prevents the omission of the mandatory secondary radiation code and stops MRONJ cases from being miscoded to M27.2 instead of M87.180.

See how Mira captures M27.2 documentation

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